Tendinopathy is a persistent disease of the tendons associated with chronic low grade inflammation and degenerative changes. Risk factors of tendinopathy include overuse, aging, and a sedentary lifestyle. Bergapten (BeG) is a compound of the furanocoumarin family, which is contained in extracts of citrus plants, figs, and celery. Although, BeG has been reported to exert antioxidant effects, its protective effects on the tendon are not fully understood. We aimed to induce a pathological condition through oxidative stress and to explore potential strategies for its improvement in tenocytes. Tenocytes were pretreated with BeG and then exposed to H_​2​O_​2. Cell viability was evaluated using a WST assay. DCFH-DA staining was used to detect reactive oxygen species (ROS) level. Scratch healing assay was used to identify cell migration ability. Western blotting was used to assess the protein expression levels of antioxidant enzymes, ferroptosis markers, ECM-related markers, and inflammatory markers. The effects of BeG in H​_​2​O_​2-treated tenocytes were abrogated by compound C. These results demonstrated that the protective effect of BeG against H​_​2​O_​2-induced tendinopathy was mediated by AMPK activation. It also reversed the expression levels of all previously mentioned markers. This study elucidates the basis for a therapeutic approach for treating tendinopathy through oxidative stress. We highlight BeG as a potential candidate and provide novel mechanistic insights.