2025 Spring International Convention of
The Pharmaceutical Society of Korea

2025 Spring
International Convention of PSK

04.21(MON) - 04.22(TUE)
D+25

Abstracts

P7-6

Anti-oxidant and anti-inflammatory effect of ethanol extract from immature Rubus coreanus fruit

  • Taw Won Kim1, Hye Kyung *1
  • 1College of Pharmacy and Brain Busan 21 Plus Research Project Group, Kyungsung University, Busan 48434, Republic of Korea

Immature Rubus coreanus (R. coreanus) fruit has been reported to have improve erectile dysfunction, anti-diabetic, anit-obesity, hepatoprotective and whitening effect. Ellagic acid is the major compound of R. coreanus and marker compound. The content of ellagic acid in immature R. coreanus extract (RCE) was quantitavely analyzed by using high-performance liquid chromatography (HPLC). The ROS and ONOO- scavenging assays were performed to evaluate the anti-oxidant effect of RCE. To investigate the anti-inflammatory properties of RCE, the gene expression of inflammatory cytokines in lipopolysaccharide (LPS)-treated RAW 264.7 cells was measured. The content of ellagic acid with RCE was 0.12%. The result of anti-oxidation with RCE showed that ROS scavenging acitivity was incresed in a concentration-dependent mannar and ONOO- scavenging activity was significant at all concentrations. When the gene expression of inflammatory cytokines was measured, it was confirmed that RCE reduced the expression of inflammatory cytokines in LPS-treated RAW 264.7cells.

 


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TODAY 2025. 05. 17

2025 Spring Convention

D+25

Conference infomation

Conference Schedule
Apr. 21(Mon) ~ 22(Tue), 2025
Conference Venue
Daegu Exhibition & Convention Center (EXCO) 10 Exco-ro, Buk-gu, Daegu, Republic of Korea
Location
Early Registration Period
Feb. 24(Mon) ~ Apr. 14(Mon), 2025
Abstract Submission Period
Feb. 24(Mon) ~ Apr. 3(Thu), 2025
Certificate of Attendance