2025 Spring International Convention of
The Pharmaceutical Society of Korea

2025 Spring
International Convention of PSK

04.21(MON) - 04.22(TUE)
D+78

Abstracts

P10-5

Exploring causative disease traits for membranous nephropathy: An exposome-wide summary-level Mendelian randomization analysis

  • Woo Vin Lee1, Heejung Ha1, Jung Mi Oh1,2, In-Wha Kim*1
  • 1College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul, Republic of Korea.
  • 2Natural Products Research Institute, Seoul National University, Seoul, Republic of Korea.

Background Due to the nature of rare autoimmune diseases, the risk factors for membranous nephropathy (MN) remain undetermined. We conducted an exposome-wide Mendelian randomization (EWMR) study to identify the causative diseases of MN. Methods We constructed genetic instruments for clinical outcomes in the FinnGen Project. To estimate the causal effect of multiple disease traits on MN, we performed two-sample Mendelian randomization analysis. First, we utilized the full set of instrumental variables (IVfull) to identify traits suggestive of a causal effect with statistical significance. We then determined conclusive causative traits that fulfill two criteria: (1) IVfull consisted of two or more instruments and (2) the effect remained significant after excluding instruments located in the MHC region (IVnomhc). Results We included 451 traits satisfying the eligibility criteria for EWMR analysis. EWMR utilizing IVfull revealed 53 clinical outcomes with a suggestive causal effect on MN. Although the effect was attenuated when using IVnomhc, celiac disease (ORfull: 1.49; Pfull: 2.52×10-5; ORnomhc: 1.57; Pnomhc: 1.77×10-6) and colorectal cancer (ORfull: 1.53; Pfull: 5.44×10-6; ORnomhc: 1.53; Pnomhc: 5.44×10-6) were identified as conclusive causal traits of MN with robust statistical significance. Conclusion We revealed causal exposures of MN at the exposome level, suggesting the importance of preventive strategies for MN in individuals with celiac disease or colorectal cancer.


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TODAY 2025. 07. 09

2025 Spring Convention

D+78

Conference infomation

Conference Schedule
Apr. 21(Mon) ~ 22(Tue), 2025
Conference Venue
Daegu Exhibition & Convention Center (EXCO) 10 Exco-ro, Buk-gu, Daegu, Republic of Korea
Location
Early Registration Period
Feb. 24(Mon) ~ Apr. 14(Mon), 2025
Abstract Submission Period
Feb. 24(Mon) ~ Apr. 3(Thu), 2025
Certificate of Attendance