Annulative functionalization approach to poly-functionalized imidazo[1,2-a]pyridines
The reaction of enaminone with propargylamine allowed for a highly efficient domino process involving conjugate substitution, nucleophilic addition of the nitrogen to the pendant nitrile, and cycloisomerization, leading to a densely functionalized imidazo[1,2-a]pyridine via successive double ring closure.
2025 Spring Convention