Bone marrow toxicity is a side effect of chemotherapy caused by anticancer drugs or exposure to chemicals such as benzene. Since the bone marrow is the center of blood cell production, when bone marrow toxicity occurs, white blood cells responsible for providing immunity, red blood cells that carry oxygen, and normal blood cells are destroyed. The purpose of this experiment was to investigate whether Angelica gigas Nakai extract (AGNEX) and green coffee bean extract (GCBE) can enhance immune function, including the increase of white blood cells, and prevent bone marrow toxicity. Sprague Dawley rats (6 weeks old, N=9/group) were injected intraperitoneally with benzene (1 mL/kg mixed with corn oil 1:1) once every 2 days. AGNEX (12 mg/kg) and GCBE (6, 12, 24 mg/kg) were orally administered daily for 35 days. AGNEX and GCBE were administered prior to benzene administration to evaluate preventive effects. As a result, AGNEX and GCBE demonstrated preventive effects against the benzene-induced decrease in white blood cells, lymphocytes, and granulocytes. They also showed potential for prevention in the bone marrow. Additionally, a protective effect against spleen damage was observed, and GCBE specifically protected against changes in spleen body weight. Through these protective effects, AGNEX and GCBE show potential in preventing bone marrow toxicity by improving immune function.