Optimization of reaction conditions in polymer synthesis: Insights from Passerini three-component reactions
The advancements in polymer synthesis incorporating multicomponent reactions (MCRs) have captured significant attention among researchers, infusing the field of polymer synthesis with renewed vigor and significance. MCRs can be broadly categorized into non-isocyanide-based reactions (such as Biginelli and Hantzsch reactions) and isocyanide-based reactions (such as Passerini and Ugi reactions). Among these, the Passerini three-component reaction (3CR) has emerged as a particularly promising and influential technique in both drug discovery and product synthesis. In this study, the reaction involves carboxylic acid-functionalized polyethylene glycol reacting with dicarboxylic acid, aldehyde and dinitrile through Passerini 3CR reactions. To enhance the efficiency of these reactions, factors such as the choice of polymerization solvent, temperature, catalyst, and the relative proportions of each component are investigated. Characterization of the resulting structure polymers is conducted using 1H NMR. The study aims the significance of Passerini 3CR reactions in polymer synthesis and highlights the importance of optimizing reaction conditions for efficient polymerization. These findings contribute to the growing body of knowledge in the field and pave the way for further advancements in polymer science and technology.
2024 Spring Convention