The purpose of this study is to make a scale-up strategy with Engineering modeling of edoxaban tablet\'s wet-granulation process parameters that were designed at a lab-scale using DoE. Risk Assessment was conducted at a lab-scale(1L). Process Parameters that could affect the Critical Quality Attribute of the tablet were selected. The rpm of granulator\'s Agitator(X1: 185-285 rpm), granulation time(X2: 1-5 min), and the amount of DW used per tablet(X3: 0.04-0.06 ml/T) were set as independent variables. Dissolution rate(Y1: Dis_10m, Y2: Dis_15min) and Tablet hardness(Tab.H; Y3) were set as dependent variables. A Full factorial design was applied. P-value of model that was verified by regression analysis with minitab software was statistically significant(p≤0.05). A target range for each Y factor was set(Dis_10m: 65-85%, Dis_15min: 73-93%, Tab.H: 7 kp or more) and multidimensional Design Space was derived. The main effect of X1 had a more dominant influence on Y2 and Y3 than other X factors through Pareto chart. The X1 was set according to a rotation radius for each working capacity(1L, 2.5L, 50L) of the granulator using the Froude number. Scale-up was conducted and results were as follows: [1L] Dis_10min: 76.8%, Dis_15min: 84.7%, Tab.H: 8.6 kp, [2.5L] Dis_10min: 71.6%, Dis_15min: 85.4%, Tab.H: 8.8 kp, [50L] Dis_10min: 78.3%, Dis_15min: 87.1% and Tab.H: 9.5 kp.