Excessive inflammatory reaction worsen various human diseases. Essential oils have the advantage as medicine because there is no risk of long-term genotoxicity. Asteraceae family have been used for the medicine from the past, and their bioactivities have been reported. In this study, the anti-inflammatory activity and the volatile composition of Asteraceae family essential oils were compared with each other to select candidate that are relatively safe and effective. The four essential oils used in this study were Artemisia capillaris, Aster glehnii, Dendranthema indicum, and Dendranthema zawadskii. The essential oils was extracted by hydro-distillation. The chemical composition was analyzed by GC-MS. The anti-inflammatory effect was evaluated by observing changes in the expression level of genes(IL-4, IL-5, IL-6, IL-13, TNF-α, and COX-2) involved in the inflammatory response. In evaluating anti-inflammatory activity, the activities were good in that order; A. capillaris, D. zawadskii, A. glehnii, and D. indicum. All essential oils significantly reduced IL-5, IL-6, and COX-2. But, D. indicum did not produce significant changes in IL-4, IL-13, and TNF-α. On the other hand, A. capillaris significantly reduced the expression level of six genes. According to GC-MS analysis, it was confirmed that the main components of A. capillaris are α-farnesene(33.6%), caryophyllene(19.5%), and β-pinene(8.0%), respectively. These results suggest that among Asteraceae family, A. capillaris might have a higher potential for the use as an anti-inflammatory product.​