Radiopharmaceuticals are crucial for diagnosing challenging diseases and treating rare conditions but pose radiation exposure risks to workers. The I-131 mIBG production process restricts production to protect personnel, necessitating efforts to minimize worker exposure for safe drug utilization. This study focuses on developing device to mitigate radiation exposure in two key production stages: a transport cart reducing exposure during radioisotope conveyance and a decapping device minimizing worker exposure during sample vial opening. Addressing safety concerns in transporting radioisotopes in lead-shielding containers, a specialized transport cart was created, reducing risks and radiation exposure. Automatic decapping equipment enhances safety and efficiency in the sample vial separation process, mitigating radiation exposure. The resulting equipment underwent manufacturing and simulation tests, ensuring worker familiarity before deployment in radiation work areas. Anticipated outcomes include reduced radiation exposure during tasks, emphasizing the study\'s contribution to overall production safety. This study underscores the importance of minimizing worker exposure and improving safety in radioactive drug utilization.