2024 Spring International Convention of
The Pharmaceutical Society of Korea

2024 Spring
International Convention of PSK

04.17(WED) - 04.19(FRI)
D+28

Abstracts

P6-4

Photo-induced amide bond formation via copper-catalyzed reaction of aldehydes and O-benzoyl hydroxylamines

  • Anh Thu Nguyen1, Hee-Kwon Kim*1
  • 1Department of Nuclear Medicine, Jeonbuk National University Medical School, Korea

Amide bond is an essential structure of connection forming the fundamental molecules of life including peptides, proteins, and nucleotides. In addition, amide functional groups are also found in a wide range of natural products and commercial products such as pharmaceuticals, agrochemicals, fine chemicals, and synthetic polymers. The most common synthetic method towards amides was the coupling reactions of carboxylic derivatives with amines. And, many alternative synthetic methods for amide have been developed to improve the poor activity and the use of coupling reagents in conventional reactions. Besides, photo chemical reactions have been used to form useful products. In this study, we developed a photo-induced oxidative amidation of aldehydes via reactions with O-benzoyl hydroxylamines, in the presence of copper (II) bromide as a catalyst. Under blue LED irradiation, a variety of amides was efficiently prepared in good yields under mild conditions.


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TODAY 2024. 05. 17

2024 Spring Convention

D+28

Conference infomation

Conference Schedule
Apr. 17(Wed) ~ 19(Fri), 2024
Conference Venue
BPEX (Busan Port International Exhibition & Convention Center) Busan Metropolitan City, Republic of Korea
Location
Early Registration Period
Feb. 20(Tue) ~ Apr. 3(Wed), 2024
Abstract Submission Period
Feb. 20(Tue) ~ Apr. 3(Wed), 2024
Certificate of Attendance